![]() This reduction is caused by an age-related increased degradation of LAMP-2A and an age-related reduced ability of LAMP-2A to reinsert into the lysosomal membrane. The reduced CMA in aging is due to reduced LAMP-2A in the lysosomal membrane. When CMA is activated, LAMP-2A moves out of these domains. LAMP-2A in the lysosomal membrane can be sequestered into cholesterol-rich microdomains where it is inactive. The decrease in CMA causes cells to be more susceptibile to oxidative and other stresses. Reduction of levels of LAMP-2A using RNAi strategies reduces CMA activity, but macroautophagy is activated as a result. CMA can be reduced by inhibitors of glucose-6-phosphate dehydrogenase and of the heat shock protein of 90 kDa. ![]() Recent results show that CMA is also activated by oxidative stress, and in this case LAMP-2A is increased due to transcriptional regulation. LAMP-2A levels in the lysosomal membrane can be increased by reduced degradation and/or redistribution from the lysosomal lumen to the lysosomal membrane. A critical component for CMA is a receptor in the lysosomal membrane, the lysosome-associated membrane protein (LAMP) type 2A. The molecular chaperones in the cytosol unfold substrate proteins prior to their translocation across the lysosomal membrane, while the chaperone in the lysosomal lumen is probably required to pull the substrate protein across the lysosomal membrane. Molecular chaperones in the cytosol and in the lysosomal lumen stimulate this proteolytic pathway. Chaperone-mediated autophagy (CMA) is a lysosomal pathway of proteolysis that is responsible for the degradation of 30% of cytosolic proteins under conditions of prolonged nutrient deprivation. ![]()
0 Comments
![]() ![]() Researchers at the University of Turin, Italy, found that essential oil of thyme significantly enhanced the destruction of the C. albicans) is a common cause of yeast infections in the mouth and vagina, a recurring condition called “thrush.” They found that wild thyme caused cell death in breast cancer cells. Researchers in Turkey looked at the effect of wild thyme on breast cancer activity, and specifically how it affected apoptosis, or cell death, and gene-related events in breast cancer cells. ![]() Colon cancerĪ study carried out in Lisbon, Portugal, found that extracts of mastic thyme might protect people from colon cancers. They reported that thyme oil, even at low concentrations, showed potential as a natural preservative of food products against several common foodborne bacteria that cause human illness.Ī Polish study tested thyme oil and lavender oil, and they that observed that thyme oil was effective against resistant strains of Staphylococcus, Enterococcus, Escherichia and Pseudomonas bacteria. Foodborne bacterial infectionsĪ team at the Center for Studies of Animal and Veterinary Sciences, Portugal, studied the antimicrobial activity of essential oils extracted from a range of aromatic plants, including thyme oil. More tests are required for the data to prove significant, however. Rats respond to hypertension in a similar way to people, so the findings might have implications for humans. Researchers at the University of Belgrade, Serbia, found that an aqueous extract obtained from wild thyme reduced blood pressure in tests on rats. Louis encephalitis, dengue fever, and Chikungunya fever.Ī team at Chungbuk National University in South Korea reported that a combination of thymol, alpha-terpinene, and carvacrol was effective in killing off tiger mosquito larvae. Since the 1990s, it has spread around the world, carrying West Nile virus, Yellow fever, St. The tiger mosquito is native to tropical and subtropical areas of Southeast Asia. One study from 2010 suggests that thymol can reduce bacterial resistance to common drugs, including penicillin. Used alongside other biocides, such as carvacrol, thyme has strong antimicrobial properties. These are substances that can destroy harmful organisms, such as infectious bacteria. Thymol is one of a naturally occurring class of compounds known as biocides. Share on Pinterest Thyme has a range of powerful medicinal effects. ![]() ![]() ![]() ![]() However, Tennessee arrests and criminal records can be accesses across the globe through local county inmate rosters, court case look ups, and the TN Department of Corrections Inmate Locator. Only residents of the state can access people’s Tennessee public criminal records through the Tennessee Bureau of Investigations and if a person tries to view another person’s criminal records in Tennessee, but they are not a resident, the records request will be denied due to the state’s restrictions on public information. Can Anyone Access People’s Criminal Records in Tennessee? In this case, users should consider utilizing paid search sites to find comprehensive and accurate information on the individual in question. Information that can be found includes but is not limited to:Ĭriminal records are accessible through third-party sites if users cannot find the information required through governmental resources, such as local, state, and federal websites. However, records must be requested through the Tennessee Bureau of Investigation if it’s for professional purposes (employment, licensing, housing etc.) in order to be legal. In Tennessee, criminal records are publicly accessible due to the Tennessee Freedom of Information Act. 2 Individuals with criminal records will have a rap sheet that includes their alleged crimes, charges, court records, rehabilitation information, and post-conviction status. Tennessee Criminal Records – A SummaryĬriminal records contain criminal activity and the history of a person who has had run-ins with the criminal justice system within the state of Tennessee. However, government entities can make records accessible to those who are not residents of Tennessee by special order. Therefore, every resident of Tennessee has access to public records, but not necessarily every member of the public or every record. The only information not accessible to the public includes medical records of a patient currently in state institutions, investigative records, public school records, and some economic development records. Records within the state of Tennessee are documents related to government official business and can include citizens’ records too. Records kept by agencies in Tennessee are open to the public unless they are specifically restricted. Tennessee abides by the Tennessee Open Records Act that guarantees every resident of Tennessee has access to the public records of government bodies within the state. As an employer, understanding how to do a name based or fingerprint-based check is key to screening candidates as well.Īll in all, knowing how to look up free criminal records, court records, vital records, and employment history is beneficial for all residents of Tennessee and the general public. By using state records in Tennessee for free, searchers can look up anyone’s past.Īs a curious individual, knowing how to conduct a criminal background check, see if you have a warrant for your arrest, or see if someone is married can be helpful to make an informed decision. Sheriff offices in Blount and Anderson counties also offer a listing of jail inmates.Individuals who wish to find free Tennessee public records can benefit from knowing the public record laws, which information is available to individuals, and how to perform criminal and background checks. The project, said Sheriff's Office spokeswoman Martha Dooley, was requested by Knox County Sheriff Jimmy "J.J." Jones. ![]() The listings include all inmates, including federal detainees, at the Knox County Sheriff's Detention Facility and at the main jail in the City County Building. The Sheriff's Office serves as the jail for all state and local arrests made in Knox County. Officials at the Sheriff's Office this week began listing the inmate population - complete with pictures, birth dates and charges - on its Web site at The listings include the more than 1,000 inmates held at the two facilities operated by the Sheriff's Office and it provides an alphabetical listing of those arrested in the last 24 hours. KNOXVILLE - They're not exactly dancing to the jailhouse rock, but you can now see all the inmates staying in the whole cell block thanks to the Knox County Sheriff's Office. 24 hour arrest list on the Knox County Sheriff's websiteĬurrent arrest list on the Knox County Sheriff's website ![]() ![]() ![]() ![]() Then, in the 4.4/5 star rated course Financial Modeling for Beginners in Excel in 4 Hours, you’ll learn how to use your Excel skills for first-class financial modeling. ![]() You’ll get over 43 hours of training on data visualization, analysis, formatting, formulas, and more to make you an advanced Excel master.įor example, in the 4.6/5 star rated course Microsoft Excel: Advanced Formulas & Functions, you’ll get a hands-on, practical walkthrough of over 75 advanced formulas and functions that will transform Excel from a basic spreadsheet program into the most powerful analytics tool in your arsenal - ready to apply to real-world work and your resume immediately. Not only is that a huge discount off the regular price of $2400, but with 12 different courses included, that works out to less than $3.80 a course. What’s also great about learning Excel is that you can do it in your own time, from anywhere with The 2021 Ultimate Microsoft Excel Business Intelligence Certification Bun dle - which we’ve found on sale today for just $44.99. Those strong Excel skills can translate to a serious salary bump, too, with Excel experts proven to earn thousands of dollars more than people who don’t. In fact, it’s one of the most valuable skills you can have, as it plays an important role in literally every function, in every industry. Microsoft Excel is useful for more than just making tables. ![]() ![]() ![]() Seeds the size of sand spread by wind, water, humans, and animals. Fruit: Fruit Color: Cream/Tan Fruit Type: Capsule Fruit Description: Tan capsules that appear as early as July with many tiny seeds aid in the quick dispersion of this plant.Cultural Conditions: Light: Full sun (6 or more hours of direct sunlight a day) Soil Drainage: Good Drainage Occasionally Wet USDA Plant Hardiness Zone: 3a, 3b, 4a, 4b, 5a, 5b, 6a, 6b, 7a, 7b, 8a, 8b, 9a, 9b.Whole Plant Traits: Plant Type: Herbaceous Perennial Perennial Weed Habit/Form: Erect Growth Rate: Rapid Maintenance: High. ![]() Attributes: Genus: Lythrum Species: salicaria Family: Lythraceae Life Cycle: Perennial Recommended Propagation Strategy: Division Seed Stem Cutting Country Or Region Of Origin: Europe, Africa and Asia-Temperate Distribution: Naturalized and invasive in the USA Dimensions: Height: 2 ft.Tags: #purple #showy flowers #invasive #full sun tolerant #pink flowers #high maintenance #aggressive #summer flowers #illegal #Noxious Weed List #wind dispersed seeds #water dispersed seeds #wet soils tolerant #animal dispersed seeds #perennial #weed See this plant in the following landscape: Cultivars / Varieties: This species is on the NC noxious weed list. Listed as invasive by the NC Invasive Plant Council. Insects, Diseases, and Other Plant Problems: Consider growing native plants. Purple loosestrife is not recommended nor is it legal for cultivation (is it a noxious weed in North Carolina). Named cultivars once thought to be non-invasive are now known to cross and develop strains that spread rapidly in the landscape. It is currently against the law in North Carolina and many other states to sell Purple loosestrife, because it escapes from cultivation and becomes a prolific weed in wetland areas, choking out native vegetation essential for waterfowl. The showy purple pink flowers appear from mid to late summer and are followed by capsules filled with thousands of tiny seeds that are easily dispersed by wind, water, and animals. The roots are thick and send out many runners forming an extensive underground network from which new plants can sprout. The plant will grow from 2 to 6 feet tall Commonily found growing in waste areas, roadsides, and sites with wet soil conditions. Purple loosestrife is a perennial weed in the Lythraceae (loosestrife) family native to Africa and Eurasia. Please see the suggestions in the left-hand column. This plant is problematic and alternatives should be considered. Phonetic Spelling LITH-rum sal-ih-KAIR-ee-ah This plant is an invasive species in North Carolina Description ![]() ![]() ![]() These scripts told computers how to compile projects, which executables to generate, and which libraries to create. CMake’s add_library Helps With Portabilityīefore CMake, there was a time when people wrote massive scripts for building C/C++ projects – Makefiles. Do you have certain bits of code that need to be shared with different programs/executables? Do you want to distribute some code publicly so other people can use it in their projects? Is your codebase getting ridiculously big, and you need to split parts of it into reasonable modules? Then you need to start thinking about libraries. ![]() In summary, you may need to create libraries for a few reasons. Unsurprisingly, libraries aren’t unique to C/C++!
![]() ![]() Although sales were initially sluggish, it found larger success following the advent of the 1998 holiday season and went on to sell nearly 5 million copies worldwide. ![]() Spyro the Dragon was released by Sony Computer Entertainment as part of a general effort to reach out to a younger age demographic and compete with the more popular kid's platform, the Nintendo 64. Stewart Copeland, the former drummer for The Police, composed the game's music, and the titular character was voice acted by Carlos Alazraqui, alongside additional voices done by Clancy Brown, Michael Gough and Jamie Alcroft. The game was one of the first on the PlayStation to utilize shifting levels of detail among rendered objects, thanks to a panoramic engine developed by Alex Hastings which allowed the game's open-ended nature to be fully realized. Taking inspiration from the film Dragonheart, the game started out as a more mature title with a dark and realistic approach, but the direction was shifted to have a more whimsical and light-hearted tone to appeal to a wider market of consumers. Artist Craig Stitt suggested a game about a dragon, and work began on a new game. Spyro the Dragon started development following the release of Insomniac's debut game, Disruptor, which sold poorly but was generally praised by critics, impressing Universal Interactive enough to encourage them to make a second game. Spyro's abilities as a dragon include fire breath, a head-on charging attack, and a mid-air glide which he can use to scale large distances, all of which must be used strategically to find items and defeat enemies. Spyro the Dragon is an open-ended 3D platformer, featuring large, sprawling levels in which the player must locate collectable items, among which are gemstones, crystallized dragons, and stolen dragon eggs. The first game in the Spyro series, it stars the title character, a young purple dragon named Spyro, and his dragonfly friend, Sparx, who must journey across the Dragon Kingdom to defeat Gnasty Gnorc, who has overtaken the 5 dragon Homeworlds by trapping the other dragons in crystal and turning their hoard of gems into an army of minions. Spyro the Dragon is a 1998 platform game developed by Insomniac Games and published by Sony Computer Entertainment for the PlayStation. ![]() ![]() ![]() Kubrick changed his mind after Ermey put together an instructional tape, in which he went on an extended tirade towards several extras, convincing Kubrick he was the right man for the role. Initially, he was intended to be only the technical advisor. For the next few years, Ermey played a series of minor film roles until 1987, when he was cast as drill instructor Gunnery Sergeant Hartman in Stanley Kubrick's Full Metal Jacket. Ermey then was cast as a Marine drill instructor in Sidney Furie's The Boys In Company C. He played a First Air Cavalry chopper pilot in Apocalypse Now, doubling as a technical advisor to director Francis Ford Coppola. FilmsĮrmey was cast in his first film while attending the University of Manila in the Philippines, using his G.I. Jones, becoming the first retiree in the history of the Marines to be promoted. On May 17, 2002, he received an honorary promotion to gunnery sergeant ( E-7) by the Commandant of the Marine Corps, General James L. He was medically discharged in 1972 because of several injuries incurred during his service. ![]() The remainder of his service was on Okinawa where he was advanced to staff sergeant (E-6). In 1968, he was ordered to Vietnam with MWSG-17, and spent 14 months in country. For his first few years, he served in the aviation support field before becoming a drill instructor in India Company, 3rd Recruit Training Battalion, at Marine Corps Recruit Depot San Diego, where he was assigned from 1965 to 1967.Įrmey then served in Marine Wing Support Group 17 at Marine Corps Air Station Futenma in Okinawa, Japan. ![]() In 1961, at age 17, Ermey enlisted in the United States Marine Corps and went through recruit training at Marine Corps Recruit Depot San Diego in San Diego, California. After his second arrest, a judge gave him a choice between joining the military or being sent to jail Ermey chose the former. As a teenager, Ermey often got in trouble with the local authorities, and had been arrested twice for criminal mischief by age 17. In 1958, when Ermey was 14, he and his family left Kansas and moved to Toppenish, Washington. He also hosted Gunny Time on the Outdoor channel.Įrmey was born in Emporia, Kansas, on March 24, 1944, and was raised with his five brothers on a farm outside of Kansas City, Kansas. Lee Ermey, which concerned the development of different types of weapons. "Tice" Ryan in Rocket Power, the warden in SpongeBob SquarePants, and John House, Gregory House's father in House.Įrmey has hosted two programs on the History Channel: Mail Call, in which he answered viewers' questions about various military issues both modern and historic and Lock N' Load with R. ContentsĮrmey has often been typecast in authority figure roles, such as Mayor Tilman in the film Mississippi Burning, Bill Bowerman in Prefontaine, Sheriff Hoyt in The Texas Chainsaw Massacre remake, Gunnery Sergeant Hartman in Stanley Kubrick's Full Metal Jacket, Jimmy Lee Farnsworth in Fletch Lives, a police captain in Se7en, plastic army men leader Sarge in the Toy Story films, Lt. Marine Corps, he served as a drill instructor. He is a former United States Marine Corps staff sergeant and an honorary gunnery sergeant during his tenure in the U.S. Lee Ermey, or even Lee Ermey, is an American actor and voice actor, best known for his role as Gunnery Sergeant Hartman in Full Metal Jacket, which earned him a Golden Globe Award nomination for Best Supporting Actor. Ronald Lee Ermey (born March 24, 1944), known professionally as R. ![]() ![]() The desktop app works well, but we found the mobile apps limited in confusing ways. And you can always download your videos and store them somewhere else if you're getting close to that 25 video threshold. It's limited, sure, but great for quickly showing something to a collaborator, coworker, and/or archenemy. With the free version of Loom, you can store up to 25 videos of up to five minutes each. It's all very quick, which makes it, overall, the best screen recorder for PC. You can do some basic editing in the browser, if you want, or you can copy the link to share the video. Once you finish, your video will be uploaded to Loom. Loom isn't overly complicated when it's time to record: you can choose whether you want to record just your screen, your screen with webcam video, or just your webcam. If you want to quickly record something and share a link, give Loom a chance. Many video conferencing, communication, and productivity tools-not to mention your mobile phone-have added screen recording to their feature sets, so it's worth checking if you can get the capabilities you need from a tool that's already in your stack. One thing to note: It's possible that an app you already use has screen recording built in. The quality of the final product can make or break user engagement, so we also considered the post-capture editing features. Of course, the process doesn't end with the screen recording. ![]() Simultaneous microphone and system audio recordingīuilt-in video sharing and/or convenient exporting tools The option to superimpose a webcam feed over the screen capture ![]() The ability to record your whole screen, one window/app, or a specific area Each of our picks for best screen recorder app offers a unique feature, but they all meet some basic criteria: The options are priced from free all the way up to several hundreds of dollars. In our research, we tested several dozen apps, ranging from minimalistic three-button windows to complex apps overflowing with tools. But different people are going to be looking for different things. ![]() The best screen capture software makes it really easy to show how things work-or, if you're filing a support ticket, how they don't work. For more details on our process, read the full rundown of how we select apps to feature on the Zapier blog. We're never paid for placement in our articles from any app or for links to any site-we value the trust readers put in us to offer authentic evaluations of the categories and apps we review. We spend dozens of hours researching and testing apps, using each app as it's intended to be used and evaluating it against the criteria we set for the category. All of our best apps roundups are written by humans who've spent much of their careers using, testing, and writing about software. ![]() ![]() ![]() There are no new levels, but the game is pretty fun and has uses during a party. Paradise mode and ninja mode are just there for a quick, short lived laugh. The issue here is that the new content is just for aesthetics. Ghost squad was a fun on the rails shooter in the arcades back in 2004 and this version is a good port of the original. And its $20 cheaper than most new Wii games. Training mode primarily trains you to aim without the crosshair, which is an option you can turn on/off during arcade or party mode.Ī must have for arcade and 1st person shooter fans. ![]() There are 16 levels, but each level plays out pretty much except maybe with a few more/less enemies. ![]() You have one combat training mission that is less than a minute long. The only thing keeping me from giving this game 5 stars was the training mode. Could just be me though ^.^ Also, using the Nunchuk is optional for this game. Although the zapper has no inner wiring, it makes the game a lot more fun to play, and personally I feel like my accuracy goes up a bit. If you are really into this game, I advise picking up the Wii Zapper with Link's Crossbow Training. I can be shooting a blank wall for a minute and a half until I realize that I'm not the blue crosshair. There is a party mode, in which up to four players can simultaneously play a mission, but at that point it gets kind of hard to tell all the crosshairs apart. The ability to level up your character, and missions really increases the replay value of this game. That is the other great things about this game, you can level up your missions, and your character to unlock different guns, costumes, and even different modes for the game. So Mission 1 at level 1, will be a bit different than Mission 1 at level 5. Ghost Squad is a very interactive game, not just because the Wii is motion sensor, but because the further you get in the game, the more options you unlock which take your individual missions into different direction (Mid mission you might be asked to pick whether or not you want to disarm a bomb, or save hostages-these options increase as you progress). Silent Scope, or Time Crisis), this game is definitely for you. If you are a fan of first person shooters (i.e. Point your Wii-mote at the screen, pick a mission, shoot people, point your Wii-mote off screen to reload your gun. I was a little worried that the port to Wii would lose a lot of features, and end up being dumbed down, but I have to say, aside from missing the big plastic AK47 and the huge tv, this game is very well done. I was very excited to see that this game was being released for the Wii, since its arcade counterpart is my most frequented game at the arcade. ![]() |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |